ON THE NATURE OF SISTER-CHROMATID EXCHANGES IN 5-BROMODEOXYURIDINE-SUBSTITUTED CHROMOSOMES
نویسندگان
چکیده
منابع مشابه
On the nature of sister-chromatid exchanges in 5-bromodeoxyuridine-substituted chromosomes.
Sister-chromatid exchanges (SCE) were studied in allium cepa L. meristematic cells at the second and third divisions after BrdUrd-substitution during just the first or during the second and third cycles, respectively. The observed SCE nonreciprocal/reciprocal ratios detected at the third division in both experiments, as well as comparison of the lowest SCE frequency observed per cycle and expre...
متن کاملNew staining method for the detection of sister-chromatid exchanges in BrdU-labelled chromosomes.
A direct Giemsa technique is described for the selective staining of Brd-U-substituted chromatin. It can advantageously be used for sister-chromatid exchange analysis and for the detailed cytological study of the mouse kinetochores. Presumptive inversions within the centromeric region of chromosomes 4 and 18 in the C57Black/6J mouse are described.
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The sister chromatid exchange test is regarded as a highly sensitive cytogenetic assay. It measures chromosome sensitivity to particular damage factors and provides information on control and repair mechanism performance. It is instrumental in the early identification of the effects of noxious factors present in the habitat. This investigation was aimed at identifying sister chromatid exchange ...
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The potential mutagenicity of isoflurane was investigated by the sister chromatid exchange (SCE) test using peripheral blood lymphocytes from patients before and after anaesthesia. Thirty patients, aged 18-59 yr (median 29.5 yr), were anaesthetized for minor orthopaedic operations with isoflurane and nitrous oxide in oxygen for 37-90 min (median 64 min). Venous blood samples were drawn before t...
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The relationship between the 'spontaneous' frequency of sister-chromatid exchanges (SCE) and tumorigenicity was studied in a series of hybrids between a C57BL melanoma cell line and diploid cells, but no correlation was found between the 2 variables. Hybrids in which malignancy was suppressed and malignant segregants derived from them showed virtually identical SCE frequencies. Variation of SCE...
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ژورنال
عنوان ژورنال: Genetics
سال: 1979
ISSN: 1943-2631
DOI: 10.1093/genetics/92.4.1251